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al., 2003 In animals consuming carbohydrate-containing diets, enzymatic activity helps facilitate the breakdown of starch before it reaches the hindgut, where excessive fermentation can sometimes contribute to digestive disturbances

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Mechanistically, these catechol estrogens selectively target and inhibit PDI’s enzymatic activity, and abrogate PDI-mediated nNOS and iNOS dimerization and NO accumulation, which then leads to reduction in cellular ROS and lipid-ROS accumulation